The main focus of our laboratory is the interplay between the immune system and cancer. To understand why the immune response vastly differs between cancer patients, we work at the intersection of computational systems biology and experimental tumor immunology. We analyze large-scale human datasets to identify candidate genetic features that modulate anti-tumor immunity, and we investigate their mechanistic role using a broad toolset including animal cancer models, in-vitro co-culture systems, and cutting-edge single cell genomics approaches. We are privileged to be part of Berlin’s vibrant research community and maintain collaborations to both clinical and basic science laboratories, both in Berlin and beyond. We would love to hear from you if you want to chat about science, potential ideas, or if you are interested in joining our pursuit of unraveling the complex but fascinating unknowns in tumor immunology.

Germline variation in anti-tumor immunity

Assessing the impact of germline genetics on anti-tumor immunity

Resistance against cancer immunotherapy

Elucidating the molecular determinants of resistance against cancer immunotherapy

Single cell genomics in anti-tumor immunity

Charting anti-tumor immune states with single-cell genomics