Our paper on the impact of APOE germline variants on tumor immunity is out in Nature Medicine
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We are very excited that our paper on the role of germline variants in the APOE gene is out in Nature Medicine today! 🎉🥳
It remains poorly understood why some patients mount effective anti-tumor immune responses that can be re-invigorated with immunotherapy while others don’t. Our work provides evidence that variants in the genes we are born with (the germline genetic make-up) modulate anti-tumor immunity. In this paper, we show that highly common variants of APOE, present in ~40% of the general population and known as the biggest risk factor for Alzheimer’s disease, significantly modulate anti-tumor immunity in melanoma. Huge thank you to everyone involved!